The NOD2 Polyclonal Antibody (CAB15992) is a valuable tool for researchers studying NOD2, a key player in the innate immune response. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the NOD2 protein, it enables researchers to detect and analyze NOD2 expression in various cell types, making it ideal for studies in immunology and infectious disease research.NOD2 is a cytosolic pattern recognition receptor that plays a crucial role in detecting bacterial infections and activating inflammatory responses.
Mutations in NOD2 have been linked to autoimmune diseases and increased susceptibility to bacterial infections. Understanding the function of NOD2 is essential for developing targeted therapies for these conditions.Overall, the NOD2 Polyclonal Antibody is a valuable tool for researchers looking to investigate the role of NOD2 in immune responses and disease pathology. Its high specificity and reliability make it a trusted reagent for studies in the field of immunology.
Product Name:
NOD2 Rabbit Polyclonal Antibody
SKU:
CAB15992
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-216 of human NOD2 (NP_071445.1).
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
64127
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human colon using NOD2 Rabbit pAb (CAB15992) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
