NOD2 Rabbit Polyclonal Antibody (CAB15992)
- SKU:
- CAB15992
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | NOD2 Rabbit Polyclonal Antibody |
SKU: | CAB15992 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-216 of human NOD2 (NP_071445.1). |
Sequence: | SQEA FQAQ RSQL VELL VSGS LEGF ESVL DWLL SWEV LSWE DYEG FHLL GQPL SHLA RRLL DTVW NKGT WACQ KLIA AAQE AQAD SQSP KLHG CWDP HSLH PARD LQSH RPAI VRRL HSHV ENML DLAW ERGF VSQY ECDE IRLP IFTP SQRA RRLL DLAT VKAN GLAA FLLQ HVQE LPVP LALP LEA |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1; NOD2 |
Positive Sample: | Mouse kidney,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | basolateral plasma membrane, cell surface, cytoplasm, cytoskeleton, cytosol, Golgi apparatus, mitochondrion, phagocytic vesicle, plasma membrane |
Calculated MW: | 115kDa |
Observed MW: | 100kDa |
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 64127 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |