NOD1 Rabbit Polyclonal Antibody (CAB1246)
- SKU:
- CAB1246
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | NOD1 Rabbit Polyclonal Antibody |
SKU: | CAB1246 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human NOD1 (NP_006083.1). |
Sequence: | MEEQ GHSE MEII PSES HPHI QLLK SNRE LLVT HIRN TQCL VDNL LKND YFSA EDAE IVCA CPTQ PDKV RKIL DLVQ SKGE EVSE FFLY LLQQ LADA YVDL RPWL LEIG FSPS LLTQ SKVV VNTD PVSR YTQQ LRHH LGRD SKFV LCYA QKEE LLLE EIYM DTIM ELVG FSNE SLGS LNSL ACLL DHTT GILN EQGE TIFI LGDA GVGK SMLL QRLQ SLWA TGRL DAGV KFFF HFRC RMFS CFKE SDRL CLQD LLFK HYCY PERD PEEV FA |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | CARD4; NLRC1; CLR7.1; NOD1 |
Positive Sample: | LO2,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Apical cell membrane, Basolateral cell membrane, Cell membrane, Cytoplasm. |
Calculated MW: | 108kDa |
Observed MW: | 108kDa |
This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients.
Purification Method: | Affinity purification |
Gene ID: | 10392 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |