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NNMT Monoclonal Antibody [PAT11G11AT] (CPAB0219)

SKU:
CPAB0219
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a 
Clone:
PAT11G11AT
Applications:
ELISA
FC
€149
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Description

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NNMT Monoclonal Antibody [PAT11G11AT] (CPAB0219)

The NNMT Polyclonal Antibody (CPAB0219) is a valuable tool for researchers studying Nicotinamide N-methyltransferase (NNMT), an enzyme involved in the methylation of nicotinamide and other pyridines. This antibody, produced in rabbits, is highly specific to human NNMT and has been validated for use in applications such as Western blotting.NNMT is known to play a role in various cellular processes, including energy metabolism and inflammation regulation. Dysregulation of NNMT has been implicated in diseases such as cancer, metabolic disorders, and inflammatory conditions.

By targeting NNMT with this antibody, researchers can explore its function and potential as a therapeutic target in these diseases.This NNMT Polyclonal Antibody is a reliable tool for detecting NNMT protein expression in various cell types, making it a valuable asset for studies focused on understanding NNMT's role in disease pathogenesis and identifying novel treatment strategies. With its high specificity and sensitivity, this antibody is an essential addition to any immunology or cancer research toolkit.

Product Name:NNMT Antibody
Product Sku:CPAB0219
Size:5μg
Host Species:Mouse
Immunogen:Anti-human NNMT mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NNMT protein 1-264 amino acids purified from Ecoli.
Clone:PAT11G11AT.
Reactivity:Human
Applications:ELISA, Flow Cytometry
Purification Method:NNMT antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a 
Background:NNMT is part of the family of transferases, especially those transferring one-carbon group methyltransferases. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is significant for biotransformation of many drugs and xenobiotic compounds. NNMT is accountable for the enzymatic activity which uses S-adenosyl methionine as the methyl donor. NNMT expression is related with tumor stage and DFS time in hepatocellular carcinoma cases. NNMT is a good candidate as a tumor marker of various kinds of cancers. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
Synonyms:Nicotineamide N-methyltransferase.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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