The NMNAT3 Polyclonal Antibody (CAB14465) is a valuable tool for researchers studying NMNAT3, a key enzyme involved in cellular energy metabolism and stress response pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting NMNAT3 in human samples, particularly in Western blot applications. By binding specifically to NMNAT3 protein, this antibody allows for accurate detection and quantification in a variety of cell types, making it ideal for investigations in metabolic diseases, neurodegenerative disorders, and aging-related research.NMNAT3 is a critical enzyme that catalyzes the biosynthesis of NAD+, a key molecule involved in various cellular processes, including DNA repair, energy production, and cell signaling.
Dysregulation of NMNAT3 has been linked to metabolic disorders, neurodegeneration, and aging-related conditions, making it an attractive target for therapeutic interventions. By studying the expression and activity of NMNAT3, researchers can gain insights into potential treatment strategies for diseases associated with NAD+ deficiency.Overall, the NMNAT3 Polyclonal Antibody (CAB14465) offers researchers a reliable tool for investigating the role of NMNAT3 in cellular metabolism and stress response pathways, with the potential to contribute to the development of novel therapeutic approaches for a range of diseases.
Product Name:
NMNAT3 Rabbit Polyclonal Antibody
SKU:
CAB14465
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NMNAT3 (NP_835471.1).
This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
349565
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NMNAT3 Rabbit pAb (CAB14465) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
