The NMNAT1 Polyclonal Antibody (CAB6672) is a valuable tool for research involving NMNAT1, a protein involved in multiple cellular processes, including NAD biosynthesis and neuronal survival. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in immunohistochemistry (IHC) and Western blot applications.NMNAT1 is known for its role in maintaining cellular health and promoting neuronal survival, making it a key player in neurodegenerative diseases such as Alzheimer's and Parkinson's.
By targeting NMNAT1 with this antibody, researchers can investigate its expression levels and distribution in different cell types and tissues, providing valuable insights into its function and potential therapeutic applications.The NMNAT1 Polyclonal Antibody is a versatile tool for studying the biology of NMNAT1 and its implications in neurodegenerative disorders. Its specificity and sensitivity make it an ideal choice for researchers in the fields of neuroscience, cell biology, and drug discovery.
Product Name:
NMNAT1 Rabbit Polyclonal Antibody
SKU:
CAB6672
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human NMNAT1 (NP_073624.2).
This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15.
Purification Method:
Affinity purification
Gene ID:
64802
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from LO2 cells, using NMNAT1 Rabbit pAb (CAB6672) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
