The NMNAT1 Polyclonal Antibody (CAB4937) is a valuable tool for researchers studying NMNAT1, a key enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the NMNAT1 protein, researchers can easily detect and analyze its expression in various cell types, making it an ideal choice for studies in metabolism, aging, and neurodegenerative diseases.NMNAT1 plays a crucial role in maintaining cellular NAD levels, which are essential for numerous biological processes including energy metabolism, DNA repair, and cell signaling.
Dysregulation of NAD metabolism has been implicated in various age-related diseases such as Alzheimer's and Parkinson's, making NMNAT1 a key target for therapeutic intervention. Understanding the function of NMNAT1 is vital for developing strategies to prevent or treat these debilitating conditions.Overall, the NMNAT1 Polyclonal Antibody offers researchers a reliable tool for investigating the role of NMNAT1 in cellular metabolism and aging-related pathologies, paving the way for the development of novel therapeutic approaches.
Product Name:
NMNAT1 Polyclonal Antibody
SKU:
CAB4937
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human NMNAT1 (NP_073624.2).
This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15.
Purification Method:
Affinity purification
Gene ID:
64802
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NMNAT1 Rabbit pAb (CAB4937) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
