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NME2 Monoclonal Antibody [PAT5F4AT] (CPAB0266)

SKU:
CPAB0266
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT5F4AT
Applications:
WB
ELISA
€149
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Description

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NME2 Monoclonal Antibody [PAT5F4AT] (CPAB0266)

The NME2 Polyclonal Antibody (CPAB0266) is a valuable tool for researchers studying NME2, a protein involved in various cellular processes such as DNA repair, regulation of gene expression, and apoptosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting and immunohistochemistry applications.NME2, also known as nucleoside diphosphate kinase B, plays a crucial role in maintaining genomic stability and cellular proliferation. Dysregulation of NME2 has been linked to cancer development and progression, highlighting its potential as a therapeutic target.

By utilizing the NME2 Polyclonal Antibody, researchers can detect and analyze NME2 expression in different cell types, advancing our understanding of its function and potential implications in cancer research and drug development.Overall, the NME2 Polyclonal Antibody is a reliable tool for investigating the role of NME2 in cellular processes and disease pathways, making it an essential component for studies in molecular biology, cancer biology, and drug discovery.

Product Name:NME2 Antibody
Product Sku:CPAB0266
Size:5μg
Host Species:Mouse
Immunogen:Anti-human NME2 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NME2 amino acids 1-152 purified from Ecoli.
Clone:PAT5F4AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:NME2 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2b
Background:NME2 takes an important part in the synthesis of nucleoside triphosphates other than ATP. NME2 negatively controls Rho activity by interacting with AKAP13/LBC. NME2 acts as a transcriptional activator of the MYC gene. NME2 binds DNA non-specifically. NME2 is a heterodimeric enzyme functioning as a nucleoside diphosphate kinase. NME1 and NME2 contain 152 amino acids, A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases participate in the synthesis of nucleoside triphosphates, and NM23 is involved in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways.
Synonyms:Nucleoside diphosphate kinase B, NDPK-B, NDPKB, NM23-H2, NM23B, EC 2.7.4.6, NDP kinase B, C-myc purine-binding transcription factor PUF, NDK B, NME2, puf, MGC111212.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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