The NME1 Polyclonal Antibody (CAB0259) is a reliable tool for researchers studying NME1, a protein involved in various cellular processes, including tumor suppression, metastasis, and cell differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting NME1 in human samples, making it suitable for Western blot applications.NME1, also known as nucleoside-diphosphate kinase 1, is a multifunctional enzyme that plays a critical role in regulating cell growth, migration, and invasion. Dysregulation of NME1 has been implicated in several types of cancer, making it a promising target for cancer research.
The NME1 Polyclonal Antibody enables the detection and analysis of NME1 in different cell types, providing valuable insights into its role in cancer progression and metastasis.By using the NME1 Polyclonal Antibody in their research, scientists can further explore the mechanisms underlying NME1 function and its potential as a therapeutic target in cancer treatment. Its specificity and reliability make it an essential tool for studies aiming to unravel the complexities of NME1 signaling pathways and its impact on cancer development.
Product Name:
NME1/NM23A Rabbit Polyclonal Antibody
SKU:
CAB0259
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 77-177 of human NME1/NM23A (NP_937818.1).
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Purification Method:
Affinity purification
Gene ID:
4830
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NME1/NM23A Rabbit pAb (CAB0259) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
