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NME1 Monoclonal Antibody [PAT5F4AT] (CPAB0672)

SKU:
CPAB0672
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b 
Clone:
PAT5F4AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

NME1 Monoclonal Antibody [PAT5F4AT] (CPAB0672)

The NME1 Polyclonal Antibody (CPAB0672) is specially designed for researchers studying NME1, a nucleoside diphosphate kinase involved in various cellular processes, including cell proliferation and differentiation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot and immunohistochemistry applications. By binding to the NME1 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal tool for studying cell signaling pathways and cancer biology.

NME1, also known as nm23-H1, is a multifunctional protein with roles in nucleotide metabolism, DNA repair, and cell motility. Its involvement in tumor suppression and metastasis inhibition makes it a key player in cancer research, with potential implications for developing targeted therapies. Understanding the function and regulation of NME1 is crucial for unraveling its complex roles in cellular physiology and disease progression, offering insights into novel treatment strategies for cancer and other diseases.

Product Name:NME1 Antibody
Product Sku:CPAB0672
Size:5μg
Host Species:Mouse
Immunogen:Anti-human NME1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NME1 amino acids 1-152 purified from Ecoli.
Clone:PAT5F4AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:NME1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2b 
Background:NDK (Nucleoside diphosphate kinase) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by NME2) isoforms. NME1 is involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. It also has tumor metastasis-suppressive capacity. NME1 has a key role in the synthesis of nucleoside triphosphates other than ATP. NME1 is essential for neural development including neural patterning and cell future determination.  The NME1 gene is expressed in various tumor types where its levels have been alternatively linked to reduced or increased metastatic potential.  Decrease in NME1 expression is notably connected to aggressive behavior in melanoma, breast, colon, and gastric carcinomas. In contrast, elevated levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas. Somatic mutations of the NME1 gene are found in neuroblastoma. Increased NME1 in neuroblastoma is linked to features of the disease that are associated with aggressive tumors.
Synonyms:Nucleoside diphosphate kinase A, NDP kinase A, NDK A, Tumor metastatic process-associated protein, Metastasis inhibition factor nm23, nm23-H1, Granzyme A-activated DNase, GAAD, NME1, NDPKA, NM23, NB, AWD, NBS, NDPK-A.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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