The NMDAR2A Rabbit Monoclonal Antibody (CAB19089) is a powerful tool for researchers studying the NMDAR2A protein, a key player in synaptic transmission and plasticity in the brain. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting NMDAR2A in human samples, making it ideal for use in Western blotting and other experimental applications.NMDAR2A, a subunit of the N-methyl-D-aspartate receptor (NMDAR), is essential for various functions in the central nervous system, such as learning, memory, and neuronal development. Dysregulation of NMDAR2A activity has been linked to neurological disorders like Alzheimer's disease, schizophrenia, and epilepsy, making it a crucial target for therapeutic interventions.
By using the NMDAR2A Rabbit Monoclonal Antibody in their research, scientists can gain valuable insights into the role of NMDAR2A in neurobiology and potentially identify new therapeutic strategies for treating neurological conditions associated with NMDAR dysfunction. This antibody's high specificity and sensitivity make it a reliable choice for researchers seeking to further understand the mechanisms underlying brain function and dysfunction.
Product Name:
NMDAR2A Rabbit Monoclonal Antibody
SKU:
CAB19089
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1300-1400 of human NMDAR2A (Q12879).
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2903
Clone Number:
ARC0410
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using NMDAR2A Rabbit mAb (CAB19089) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
