The NMBR Polyclonal Antibody (PACO55686) is a valuable tool for researchers studying the neurotensin receptor 1, also known as NMBR. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blotting. By specifically binding to the NMBR protein, this antibody allows for accurate detection and analysis in a range of cell types, making it ideal for investigations in neuroscience and drug development.NMBR is a G protein-coupled receptor that plays a key role in mediating the effects of neurotensin, a peptide involved in the regulation of neurotransmission, pain perception, and stress responses.
Dysregulation of NMBR has been implicated in various neurological disorders, making it a promising target for therapeutic interventions. Research on NMBR and its signaling pathways is essential for understanding the mechanisms underlying these conditions and developing targeted treatments to address them.
Antibody Name:
NMBR Antibody (PACO55686)
Antibody SKU:
PACO55686
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Neuromedin-B receptor protein (1-41AA)
Western Blot. Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate. All lanes: NMBR antibody at 4.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa.
Background:
Receptor for neuromedin-B.
Synonyms:
Neuromedin-B receptor (NMB-R) (Epididymis tissue protein Li 185a) (Neuromedin-B-preferring bombesin receptor), NMBR
UniProt Protein Function:
NMBR: Receptor for neuromedin-B. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integralChromosomal Location of Human Ortholog: 6q24.1Cellular Component: cytoplasm; integral to plasma membrane; plasma membraneBiological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
UniProt Protein Details:
NCBI Summary:
This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
