The NMBR Polyclonal Antibody (PACO02932) is a specialized tool for researchers studying the role of the neuromedin B receptor (NMBR) in various biological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the NMBR protein, this antibody allows for precise detection and analysis of NMBR expression in different cell types.NMBR is a key receptor involved in the regulation of diverse physiological functions, including the modulation of neurotransmitter release, gastrointestinal motility, and stress responses. Dysregulation of NMBR signaling has been implicated in several diseases, making it a promising target for therapeutic interventions.
Research focused on understanding the mechanisms underlying NMBR activity may lead to the development of novel treatments for conditions such as anxiety disorders, gastrointestinal disorders, and neurobehavioral conditions.Overall, the NMBR Polyclonal Antibody is a valuable tool for scientists interested in unraveling the complex roles of NMBR in health and disease. Its specificity and sensitivity make it an essential component for studies in neuroscience, endocrinology, and pharmacology, providing insights that may ultimately lead to the development of targeted therapies for a range of disorders.
Antibody Name:
NMBR Antibody
Antibody SKU:
PACO02932
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human NMBR.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
NMBR; Neuromedin-B receptor; NMB-R; Epididymis tissue protein Li 185a; Neuromedin-B-preferring bombesin receptor
UniProt Protein Function:
NMBR: Receptor for neuromedin-B. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integralChromosomal Location of Human Ortholog: 6q24.1Cellular Component: cytoplasm; integral to plasma membrane; plasma membraneBiological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
UniProt Protein Details:
NCBI Summary:
This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
