The NLRP6 Polyclonal Antibody (CAB15628) is a valuable tool for researchers studying NLRP6, a member of the NOD-like receptor family involved in inflammatory response and immune regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the NLRP6 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in immunology and inflammatory diseases.NLRP6, also known as Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) 6, plays a crucial role in the activation of the inflammasome complex and the production of pro-inflammatory cytokines.
Its involvement in regulating immune responses and inflammatory pathways makes it a key target for studies on diseases such as inflammatory bowel disease, autoimmune disorders, and metabolic diseases. The NLRP6 Polyclonal Antibody provides researchers with a reliable tool for investigating the function and expression of NLRP6, aiding in the development of potential therapeutic strategies targeting this pathway.
Product Name:
NLRP6 Rabbit Polyclonal Antibody
SKU:
CAB15628
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-110 of human NLRP6 (NP_612202.2).
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
171389
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NLRP6 antibody (CAB15628) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
