The NLRP5 Polyclonal Antibody (CAB9886) is a crucial tool for researchers studying the NLRP5 protein, a key player in the inflammasome complex involved in immune responses and inflammatory processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to NLRP5, this antibody enables the detection and analysis of the protein in various cell types, offering valuable insights for studies in immunology and autoinflammatory diseases.NLRP5, also known as NLR family pyrin domain containing 5, is essential for the activation of the NLRP3 inflammasome and the subsequent release of pro-inflammatory cytokines.
Dysregulation of NLRP5 has been linked to various inflammatory conditions, making it a promising target for therapeutic interventions. Research on NLRP5 can provide valuable insights into the mechanisms underlying inflammatory responses and aid in the development of targeted therapies for inflammatory disorders.By using the NLRP5 Polyclonal Antibody (CAB9886), researchers can further explore the role of NLRP5 in immune signaling pathways, inflammation, and disease progression, paving the way for new treatment strategies and therapeutic interventions in inflammatory and autoimmune conditions.
Product Name:
NLRP5 Rabbit Polyclonal Antibody
SKU:
CAB9886
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 157-256 of human NLRP5 (NP_703148.4).
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis.
Purification Method:
Affinity purification
Gene ID:
126206
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of SKOV3 cells, using NLRP5 Antibody (CAB9886) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20S.
