NLRP4 Antibody (PACO20063)
- SKU:
- PACO20063
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NLRP4 Antibody (PACO20063)
The NLRP4 Polyclonal Antibody (PACO20063) is an essential tool for researchers studying NLRP4, a key protein involved in the regulation of immune responses and inflammation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By specifically binding to the NLRP4 protein, researchers can accurately detect and analyze its expression in various cell types, making it a valuable asset for studies in immunology and inflammatory diseases.
NLRP4, a member of the NOD-like receptor (NLR) family, plays a crucial role in the activation of inflammasomes and the subsequent regulation of inflammatory processes. Its involvement in immune signaling pathways makes it a promising target for research related to autoimmune disorders, infectious diseases, and inflammatory conditions. By gaining a deeper understanding of NLRP4 function, researchers can potentially uncover new therapeutic strategies for treating a range of immune-related disorders.
| Antibody Name: | NLRP4 Antibody (PACO20063) |
| Antibody SKU: | PACO20063 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human NLRP4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20063(NLRP4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20063(NLRP4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes |
| Synonyms: | NLR family, pyrin domain containing 4 |
| UniProt Protein Function: | NALP4: May be involved in inflammation. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 19q13.43Cellular Component: cytosolBiological Process: regulation of interferon type I production |
| UniProt Protein Details: | |
| NCBI Summary: | NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96MN2 |
| NCBI GenInfo Identifier: | 148887404 |
| NCBI Gene ID: | 147945 |
| NCBI Accession: | Q96MN2.3 |
| UniProt Secondary Accession: | Q96MN2,Q86W87, Q96AY6 |
| UniProt Related Accession: | Q96MN2 |
| Molecular Weight: | 103,968 Da |
| NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 4 |
| NCBI Synonym Full Names: | NLR family pyrin domain containing 4 |
| NCBI Official Symbol: | NLRP4 |
| NCBI Official Synonym Symbols: | CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5 |
| NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 4 |
| UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 4 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 58; CT58; PAAD and NACHT-containing protein 2; PAN2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; PYPAF4; Ribonuclease inhibitor 2 |
| Protein Family: | NACHT, LRR and PYD domains-containing protein |
| UniProt Gene Name: | NLRP4 |
| UniProt Entry Name: | NALP4_HUMAN |
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