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NLRP3 Polyclonal Antibody (CAB24833)

SKU:
CAB24833
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
€129 - €359
Frequently bought together:

Description

Product Name:NLRP3 Polyclonal Antibody
Product Code:CAB24833
Reactivity:Human, Mouse
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse
Tested Applications:WB, IF/ICC
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm, Endoplasmic reticulum, Inflammasome, Nucleus, Secreted, cytosol

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 930-1036 human NLRP3(NP_004886.3).
Sequence:KLLCE GLLHP DCKLQ VLELD NCNLT SHCCW DLSTL LTSSQ SLRKL SLGNN DLGDL GVMMF CEVLK QQSCL LQNLG LSEMY FNYET KSALE TLQEE KPELT VVFEP SW
Synonyms:NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1, NLR family pyrin domain containing 3
Calculated MW:83kDa/105kDa/111kDa/112kDa/115kDa/118kDa
Observed MW:Refer to figures

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