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NLRP3 Polyclonal Antibody (CAB24833)

SKU:
CAB24833
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
€129 - €359
Frequently bought together:

Description

NLRP3 Polyclonal Antibody (CAB24833)

The NLRP3 Polyclonal Antibody (CAB24833) is a powerful tool for researchers studying the NLRP3 protein, a key regulator of the inflammasome pathway. This antibody, raised in rabbits, demonstrates high specificity and sensitivity for detecting NLRP3 in human samples, making it an essential tool for Western blot applications. By specifically targeting the NLRP3 protein, this antibody allows for accurate detection and analysis in various cell types, making it a valuable asset for studies in immunology and inflammatory disease research.NLRP3, also known as NOD-like receptor protein 3, plays a crucial role in the immune response by sensing danger signals and initiating inflammatory processes.

Dysregulation of the NLRP3 inflammasome has been implicated in various inflammatory conditions, including autoinflammatory diseases and metabolic disorders. Therefore, understanding the function and regulation of NLRP3 is essential for developing targeted therapies to treat inflammatory diseases effectively.Overall, the NLRP3 Polyclonal Antibody (CAB24833) is an indispensable tool for researchers investigating the role of NLRP3 in inflammation and immune responses. Its high reactivity and specificity make it a reliable choice for studies aiming to unravel the complexities of the NLRP3 inflammasome pathway.

Product Name:NLRP3 Polyclonal Antibody
Product Code:CAB24833
Reactivity:Human, Mouse
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse
Tested Applications:WB, IF/ICC
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm, Endoplasmic reticulum, Inflammasome, Nucleus, Secreted, cytosol

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 930-1036 human NLRP3(NP_004886.3).
Sequence:KLLCE GLLHP DCKLQ VLELD NCNLT SHCCW DLSTL LTSSQ SLRKL SLGNN DLGDL GVMMF CEVLK QQSCL LQNLG LSEMY FNYET KSALE TLQEE KPELT VVFEP SW
Synonyms:NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1, NLR family pyrin domain containing 3
Calculated MW:83kDa/105kDa/111kDa/112kDa/115kDa/118kDa
Observed MW:Refer to figures

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