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NLRP3 Rabbit Polyclonal Antibody (CAB12694)

SKU:
CAB12694
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-NLRP3 Antibody CAB12694
  • Immunology Antibodies 1 Anti-NLRP3 Antibody CAB12694
  • Immunology Antibodies 1 Anti-NLRP3 Antibody CAB12694
  • Immunology Antibodies 1 Anti-NLRP3 Antibody CAB12694
  • Immunology Antibodies 1 Anti-NLRP3 Antibody CAB12694
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:NLRP3 Rabbit Polyclonal Antibody
SKU:CAB12694
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant Protein corresponding to a sequence within amino acids 1-220 of human NLRP3 (NP_001120934.1).
Sequence:MKMA STRC KLAR YLED LEDV DLKK FKMH LEDY PPQK GCIP LPRG QTEK ADHV DLAT LMID FNGE EKAW AMAV WIFA AINR RDLY EKAK RDEP KWGS DNAR VSNP TVIC QEDS IEEE WMGL LEYL SRIS ICKM KKDY RKKY RKYV RSRF QCIE DRNA RLGE SVSL NKRY TRLR LIKE HRSQ QERE QELL AIGK TKTC ESPV SPIK MELL FDPD DEHS EPVH
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:AII; AVP; FCU; MWS; FCAS; KEFH; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; DFNA34; PYPAF1; AGTAVPRL; NLRP3
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Endoplasmic reticulum, Inflammasome, Nucleus, Secreted, cytosol.
Calculated MW:118kDa
Observed MW:Refer to figures

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Purification Method:Affinity purification
Gene ID:114548
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageImmunofluorescence analysis of RAW264.7 cells using NLRP3 Rabbit pAb (CAB12694) at dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.

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