The NLRP2 Polyclonal Antibody (CAB8233) is a vital tool for researchers studying NLRP2, a member of the NLR family of proteins involved in inflammasome formation and innate immune response. This antibody, produced in rabbits, is highly specific for detecting NLRP2 in human samples and has been validated for use in Western blot applications.NLRP2 plays a key role in the regulation of inflammatory responses and immune signaling pathways, making it a promising target for research in areas such as immunology, infectious diseases, and inflammatory disorders.
By using the NLRP2 Polyclonal Antibody, researchers can accurately detect and analyze NLRP2 protein expression in various cell types, allowing for a deeper understanding of its function and potential implications in disease pathology.The NLRP2 Polyclonal Antibody provides a valuable tool for investigating the role of NLRP2 in health and disease, paving the way for the development of novel therapeutic strategies targeted at modulating the immune response and inflammatory processes associated with a wide range of conditions.
Product Name:
NLRP2 Rabbit Polyclonal Antibody
SKU:
CAB8233
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 665-820 of human NLRP2 (NP_060322.1).
This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
55655
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NLRP2 antibody (CAB8233) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
