NLRP2 Rabbit Polyclonal Antibody (CAB8233)
- SKU:
- CAB8233
- Product Type:
- Antibody
- Applications:
- WB
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | NLRP2 Rabbit Polyclonal Antibody |
SKU: | CAB8233 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 665-820 of human NLRP2 (NP_060322.1). |
Sequence: | NVTA SESD AEVE RSQD DQHM LPFW TDLC SIFG SNKD LMGL AIND SFLS ASLV RILC EQIA SDTC HLQR VVFK NISP ADAH RNLC LALR GHKT VTYL TLQG NDQD DMFP ALCE VLRH PECN LRYL GLVS CSAT TQQW ADLS LALE VNQS LTCV NLSD |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | NBS1; PAN1; NALP2; PYPAF2; CLR19.9; NLRP2 |
Positive Sample: | HT-29,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 121kDa |
Observed MW: | 120kDa |
This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 55655 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |