The NLRP12 Polyclonal Antibody (CAB6671) is a valuable tool for researchers studying the NLRP12 protein, a key player in the regulation of inflammatory responses. NLRP12, a member of the NLR family of proteins, is involved in the innate immune system and has been implicated in a variety of inflammatory conditions. This antibody, produced in rabbits, has been rigorously tested and validated for use in Western blot applications, providing reliable and accurate detection of NLRP12 in human samples.
Its high reactivity and specificity make it an ideal choice for studies in immunology, inflammation, and autoimmunity. Understanding the role of NLRP12 in immune regulation and inflammation is crucial for developing targeted therapies for conditions such as autoimmune diseases, inflammatory disorders, and cancer. The NLRP12 Polyclonal Antibody is a valuable tool for researchers seeking to unravel the complex mechanisms underlying these diseases and develop new treatment strategies.
Product Name:
NLRP12 Rabbit Polyclonal Antibody
SKU:
CAB6671
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 862-1061 of human NLRP12 (NP_653288.1).
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
91662
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NLRP12 antibody (CAB6671) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
