The NLRP12 Polyclonal Antibody (CAB14519) is a valuable tool for researchers studying the NLRP12 protein, which is a crucial component of the NLRP12 inflammasome complex involved in regulating immune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the NLRP12 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for investigations in immunology and inflammatory disease research.
NLRP12 is known for its role in modulating inflammatory processes and immune system regulation, making it a key target for studying diseases such as autoimmune disorders, inflammatory conditions, and cancer. Understanding the function of NLRP12 is essential for developing targeted therapies that can manipulate immune responses in these pathological contexts. With its specificity and reliability, the NLRP12 Polyclonal Antibody is a valuable tool for advancing research in this area.
Product Name:
NLRP12 Rabbit Polyclonal Antibody
SKU:
CAB14519
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 862-1061 of human NLRP12 (NP_653288.1).
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
91662
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat spleen, using NLRP12 Rabbit pAb (CAB14519) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
