The NLRP11 Polyclonal Antibody (CAB12132) is a powerful tool for researchers studying NLRP11, a member of the NOD-like receptor (NLR) family known to be involved in inflammatory responses and immune regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.NLRP11 is a key player in the innate immune system, specifically in the activation of the inflammasome complex in response to pathogens and cellular stress. By targeting NLRP11 with this antibody, researchers can detect and analyze NLRP11 protein levels in various cell types, providing valuable insights into the molecular mechanisms underlying inflammation and immune responses.
Given the role of NLRP11 in immune regulation, this antibody is ideal for studies in immunology, infectious diseases, and inflammatory conditions. Understanding the function of NLRP11 could lead to the development of targeted therapies for conditions such as autoinflammatory disorders and infectious diseases, where dysregulation of the immune system plays a significant role.
Product Name:
NLRP11 Rabbit Polyclonal Antibody
SKU:
CAB12132
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 420-600 of human NLRP11 (NP_659444.2).
This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms.
Purification Method:
Affinity purification
Gene ID:
204801
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using NLRP11 Rabbit pAb (CAB12132) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
