The NLRP10 Polyclonal Antibody (CAB15976) is a powerful tool for researchers studying NLRP10, a member of the NLR family of proteins involved in inflammation and immune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.NLRP10, also known as NALP10 or PYNOD, is a key player in the regulation of inflammation and immunity. Its function in the NLR signaling pathway makes it a promising target for investigations into various diseases, including autoimmune disorders, inflammatory conditions, and cancer.
By binding to the NLRP10 protein, this antibody enables researchers to detect and analyze its expression in different cell types, facilitating studies in immunology and disease mechanisms.Understanding the role of NLRP10 in immune regulation is essential for developing targeted therapies that modulate inflammatory responses and immune cell activation. By utilizing the NLRP10 Polyclonal Antibody (CAB15976), researchers can further explore the functions and potential therapeutic applications of this intriguing protein in various disease contexts.
Product Name:
NLRP10 Rabbit Polyclonal Antibody
SKU:
CAB15976
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NLRP10 (NP_789791.1).
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.
Purification Method:
Affinity purification
Gene ID:
338322
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NLRP10 Rabbit pAb (CAB15976) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
