The NKX6-3 Antibody (PAC023160) is a valuable tool for researchers studying the NKX6-3 protein, an essential transcription factor involved in the development and differentiation of various cell types. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.NKX6-3 is known to play a crucial role in regulating gene expression and cellular functions, particularly in the context of development, tissue differentiation, and organogenesis. By targeting the NKX6-3 protein, this antibody enables precise detection and analysis of NKX6-3 expression in different cell types, making it ideal for studies in developmental biology, stem cell research, and regenerative medicine.
Understanding the function and activity of NKX6-3 is essential for unraveling its role in various biological processes and disease conditions. Research on NKX6-3 holds promise for insights into developmental disorders, cancer biology, and therapeutic interventions aimed at manipulating cellular differentiation and tissue regeneration. The NKX6-3 Antibody (PAC023160) provides a valuable tool for investigating the intricate mechanisms governed by the NKX6-3 protein in health and disease.
Synthesized peptide derived from internal of human NKX6.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from K562 cells and COS-7 cells, using NKX6.3 antibody.
Immunofluorescence analysis of HUVEC cells, using NKX6.3 antibody.
Background:
Putative transcription factor, which may be involved in patterning of central nervous system and pancreas By similarity.
Synonyms:
NKX63; Homeobox protein Nkx-6.3; NKX6-3;
UniProt Protein Function:
NKX6-3: Putative transcription factor, which may be involved in patterning of central nervous system and pancreas. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 8p11.21
NCBI Summary:
The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008]
