NKX2-6 Antibody (PACO22379)
- SKU:
- PACO22379
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
NKX2-6 Antibody (PACO22379)
The NKX2.6 Polyclonal Antibody (PACO22379) is a valuable tool for researchers studying the NKX2.6 protein, a transcription factor involved in the regulation of gene expression during embryonic development and in adult tissues. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. Its ability to bind to NKX2.6 allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for those conducting research in developmental biology and disease mechanisms.
NKX2.6 is known to play a critical role in cardiac development, as well as in the formation of other organs and tissues. Dysregulation of NKX2.6 expression has been linked to various congenital defects and diseases, making it an important target for further investigation. By elucidating the functions and regulatory pathways of NKX2.6, researchers can gain valuable insights into developmental processes and potentially identify novel therapeutic strategies for cardiac abnormalities and other disorders.
| Antibody Name: | NKX2-6 Antibody (PACO22379) |
| Antibody SKU: | PACO22379 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human NKX26. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HeLa cells and COLO cells, using NKX26 antibody. |
| Background: | In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development By similarity. |
| Synonyms: | CSX2; homeobox Nkx-2.6; NK2 transcription factor related; 6; NKX26 |
| UniProt Protein Function: | NKX2-6: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Defects in NKX2-6 may be a cause of conotruncal heart malformations (CTHM). CTHM defines a group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Belongs to the NK-2 homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 8p21.2Cellular Component: nucleusMolecular Function: transcription factor activityBiological Process: atrial cardiac muscle cell development; cell differentiation; embryonic heart tube development; gut development; hypothalamus development; negative regulation of apoptosis; pericardium development; pharyngeal system development; positive regulation of cell proliferation; tongue development; transcription, DNA-dependent; ventricular cardiac muscle cell developmentDisease: Conotruncal Heart Malformations |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011] |
| UniProt Code: | A6NCS4 |
| NCBI GenInfo Identifier: | 158513800 |
| NCBI Gene ID: | 137814 |
| NCBI Accession: | A6NCS4.1 |
| UniProt Secondary Accession: | A6NCS4 |
| UniProt Related Accession: | A6NCS4 |
| Molecular Weight: | 32,121 Da |
| NCBI Full Name: | Homeobox protein Nkx-2.6 |
| NCBI Synonym Full Names: | NK2 homeobox 6 |
| NCBI Official Symbol: | NKX2-6Â Â |
| NCBI Official Synonym Symbols: | CSX2; CTHM; NKX2F; NKX4-2Â Â |
| NCBI Protein Information: | homeobox protein Nkx-2.6 |
| UniProt Protein Name: | Homeobox protein Nkx-2.6 |
| UniProt Synonym Protein Names: | Homeobox protein NK-2 homolog F |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | NKX2-6Â Â |
| UniProt Entry Name: | NKX26_HUMAN |
| Antibodies |
| NKX2-6 Antibody (PACO01177) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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