The NKX2-5 Polyclonal Antibody is a valuable tool for researchers studying NKX2-5, a transcription factor critical for heart development. This antibody is produced in rabbits and is highly reactive with human samples, making it ideal for use in immunohistochemistry and other applications. By specifically binding to the NKX2-5 protein, researchers can accurately detect and analyze this important protein in various cell types.NKX2-5 is known for its role in cardiac development and function, making it a key target for research in cardiovascular biology. Mutations in the NKX2-5 gene have been associated with congenital heart defects and other cardiovascular conditions, highlighting the importance of understanding its functions.
By studying NKX2-5 using this antibody, researchers can gain valuable insights into heart development and disease, potentially leading to new therapeutic strategies for cardiac disorders.Overall, the NKX2-5 Polyclonal Antibody is a reliable tool for researchers interested in exploring the role of NKX2-5 in heart development and disease. Its high reactivity and specificity make it a valuable addition to any research laboratory focused on cardiovascular biology.
Product Name:
NKX2-5 Polyclonal Antibody
SKU:
CAB21992
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-137 of human NKX2-5 (NP_004378.1).
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1482
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NKX2-5 Rabbit pAb (CAB21992) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
