The NKX2-2 Polyclonal Antibody (CAB16696) is a valuable tool for researchers studying the NKX2-2 protein, which plays a critical role in pancreatic development and the pathogenesis of pancreatic neuroendocrine tumors. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in various applications, including immunohistochemistry and Western blotting.NKX2-2 is a transcription factor that is essential for the normal development of the pancreas, as well as for the regulation of insulin and glucagon expression. Dysregulation of NKX2-2 has been implicated in the development of pancreatic neuroendocrine tumors, a type of cancer that arises from the hormone-producing cells of the pancreas.
By studying the expression and function of NKX2-2 using this antibody, researchers can gain valuable insights into the mechanisms underlying pancreatic development and tumorigenesis. Overall, the NKX2-2 Polyclonal Antibody (CAB16696) is a reliable reagent for investigating the role of NKX2-2 in pancreatic biology and disease, with potential applications in both basic research and clinical studies. Its specificity and sensitivity make it a valuable tool for scientists looking to deepen their understanding of pancreatic development and tumorigenesis.
Product Name:
NKX2-2 Rabbit Polyclonal Antibody
SKU:
CAB16696
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human NKX2-2 (NP_002500.1).
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
Purification Method:
Affinity purification
Gene ID:
4821
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NKX2-2 Rabbit pAb (CAB16696) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5min.
