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Nkx2-2 Antibody (PACO28574)

SKU:
PACO28574
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Nkx2-2 Antibody (PACO28574)

The NKX2-2 Polyclonal Antibody (PAC028574) is a valuable tool for researchers studying NKX2-2, a transcription factor involved in pancreatic development and tumorigenesis. This antibody, raised in rabbits, exhibits high specificity and sensitivity for human samples, making it a reliable choice for Western blot applications.NKX2-2 is known for its role in pancreatic cell differentiation and has been implicated in various cancers, particularly in pancreatic neuroendocrine tumors. By targeting the NKX2-2 protein, this antibody enables accurate detection and analysis of NKX2-2 expression in different cell types, offering insights into its function and potential therapeutic implications.

Moreover, understanding the mechanisms underlying NKX2-2 activity is crucial for advancing research in pancreatic cancer and other related diseases. The availability of a validated antibody like PAC028574 facilitates the investigation of NKX2-2 biology, paving the way for innovative approaches in cancer therapy and precision medicine.

Antibody Name:Nkx2-2 Antibody (PACO28574)
Antibody SKU:PACO28574
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Homeobox protein Nkx-2.2 protein (1-273AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter.
Synonyms:Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B), Nkx2-2, Nkx-2.2 Nkx2b
UniProt Protein Function:NKX2-2: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family.Protein type: Cell development/differentiation; Transcription factorCellular Component: intracellular; nucleusMolecular Function: chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor bindingBiological Process: astrocyte differentiation; cell development; cell differentiation; endocrine pancreas development; gut development; multicellular organismal development; negative regulation of neuron differentiation; nervous system development; neuron fate specification; oligodendrocyte development; positive regulation of cell differentiation; positive regulation of neuron differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell differentiation; regulation of transcription, DNA-dependent; smoothened signaling pathway; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell differentiation; spinal cord oligodendrocyte cell fate specification; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
UniProt Code:P42586
NCBI GenInfo Identifier:6754860
NCBI Gene ID:18088
NCBI Accession:NP_035049.1
UniProt Secondary Accession:P42586
UniProt Related Accession:P42586
Molecular Weight:46.1 kDa
NCBI Full Name:homeobox protein Nkx-2.2 isoform 1
NCBI Synonym Full Names:NK2 homeobox 2
NCBI Official Symbol:Nkx2-2  
NCBI Official Synonym Symbols:Nkx2.2; tinman; Nkx-2.2  
NCBI Protein Information:homeobox protein Nkx-2.2
UniProt Protein Name:Homeobox protein Nkx-2.2
UniProt Synonym Protein Names:Homeobox protein NK-2 homolog B
Protein Family:Homeobox protein
UniProt Gene Name:Nkx2-2  
UniProt Entry Name:NKX22_MOUSE

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