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NKp46 Monoclonal Antibody [Pn1D9AT] (CPAB0509)

SKU:
CPAB0509
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
Pn1D9AT
Applications:
WB
€149
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Description

system_update_alt Datasheet

NKp46 Monoclonal Antibody [Pn1D9AT] (CPAB0509)

The NKP46 Monoclonal Antibody (CPAB0509) is an essential tool for researchers studying natural killer (NK) cells, specifically targeting the NKP46 receptor. This antibody, produced in mice, exhibits high specificity for human samples and is validated for use in flow cytometry and immunofluorescence applications.The NKP46 receptor is a key marker of NK cells and plays a crucial role in their cytotoxic activity against infected or tumor cells. By targeting this receptor with the CPAB0509 antibody, researchers can effectively identify and analyze NK cells in various experimental settings.

This makes it a valuable resource for immunologists and cancer researchers looking to investigate the function of NK cells in the immune response.With its ability to specifically bind to NKP46, the CPAB0509 antibody enables the precise detection and characterization of NK cells, shedding light on their role in the immune system's defense against pathogens and cancer. By studying the NKP46 receptor, researchers can gain insights into the mechanisms underlying NK cell activation and develop novel strategies for enhancing their anti-tumor or anti-viral functions.

Product Name:NKp46 Antibody
Product Sku:CPAB0509
Size:5μg
Host Species:Mouse
Immunogen:Anti-human NKp46 mAb, is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NKp46 amino acids 22-255 purified from Ecoli.
Clone:Pn1D9AT.
Reactivity:Other bodies
Applications:Western Blot
Purification Method:NKp46 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:A natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NKcells, and NKp44, which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. The Lysis of tumor cells by NK-cells involves recognition by NKp46 of heparan sulfate moieties of membrane heparan sulfate proteoglycans. Furthermore, NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46 (22-255aa) is purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.
Synonyms:Natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, hNKp46, NK-p46, NKp46, NK cell-activating receptor, Lymphocyte antigen 94 homolog, CD335 antigen, NCR1, LY94, NCRNKp46, CD335.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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