The NKIRAS2 Polyclonal Antibody (PAC041206) is a valuable tool for researchers studying NKIRAS2, a protein involved in the NF-kappa-B signaling pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the NKIRAS2 protein, researchers can effectively detect and analyze its presence in various cell types, making it an ideal choice for studies in immunology, inflammation, and cancer research.NKIRAS2, also known as NF-kappa-B inhibitor-interacting Ras-like protein 2, plays a crucial role in regulating NF-kappa-B activity, which is involved in a variety of cellular processes including inflammation, immune response, and cell survival.
Understanding the function of NKIRAS2 is essential for elucidating its role in various diseases such as cancer, autoimmune disorders, and inflammatory conditions. By targeting NKIRAS2, researchers may uncover potential therapeutic strategies for modulating NF-kappa-B signaling in disease settings.
Antibody Name:
NKIRAS2 Antibody (PACO41206)
Antibody SKU:
PACO41206
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 2 protein (1-191AA)
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO41206 at dilution of 1:100.
Background:
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor β (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
Synonyms:
NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (κ B-Ras protein 2) (KappaB-Ras2), NKIRAS2, KBRAS2
UniProt Protein Function:
NKIRAS2: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric, Ras; G protein; G protein, monomericChromosomal Location of Human Ortholog: 17q21.2
