The NKG2D Ligand-1 Polyclonal Antibody (CAB10483) is a powerful tool for researchers studying the NKG2D ligand family, specifically NKG2D Ligand-1. This antibody, produced using a polyclonal approach in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications.NKG2D Ligand-1 is a critical component of the immune system, playing a key role in the activation of natural killer cells and cytotoxic T cells. Its expression is often upregulated in response to cellular stress, making it a potential target for cancer therapy and immunotherapy research.
This antibody specifically binds to NKG2D Ligand-1, allowing for precise detection and analysis in various cell types.By studying the function and regulation of NKG2D Ligand-1, researchers can gain valuable insights into immune response mechanisms, particularly in the context of cancer and viral infections. This antibody is an essential tool for investigations into the role of NKG2D Ligand-1 in immune surveillance and immune evasion, offering new possibilities for targeted therapeutic interventions.
Product Name:
ULBP1 Rabbit Polyclonal Antibody
SKU:
CAB10483
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human ULBP1 (NP_079494.1).
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
80329
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Raji cells, using ULBP1 Rabbit pAb (CAB10483) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
