The NIT2 Polyclonal Antibody (PACO18756) is a valuable tool for researchers studying NIT2, a key enzyme involved in nitrogen metabolism and cellular homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the NIT2 protein, this antibody allows for the detection and analysis of NIT2 expression in various cell types, making it ideal for research in biochemistry, metabolomics, and cancer biology.
NIT2 is a crucial enzyme that plays a vital role in maintaining nitrogen balance in cells, making it a potential target for therapeutic interventions in diseases related to nitrogen metabolism dysregulation. By studying the activity of NIT2, researchers can gain insights into metabolic pathways and potential therapeutic strategies for metabolic disorders and cancer. The NIT2 Polyclonal Antibody is essential for elucidating the biological function of NIT2 and its implications in disease pathology.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18756(NIT2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue, Mouse kidney tissue, Primary antibody: PACO18756(NIT2 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18756(NIT2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle.
Synonyms:
Itrilase family, member 2
UniProt Protein Function:
NIT2: a protein of unknown function. A CN hydrolase domain suggests that this protein may be involved in nitrilase-related metabolism and handling.
