The NIPBL Antibody (PACO50678) is a polyclonal antibody designed for research involving NIPBL, a protein involved in the regulation of gene expression and cell cycle progression. The antibody, raised in rabbits, is highly specific for detecting NIPBL in human samples and is validated for use in Western blot applications. It binds to the NIPBL protein, allowing for accurate detection and analysis in various cell types, making it well-suited for studies in cell biology and developmental biology.NIPBL, also known as the Nipped-B-like protein, plays a crucial role in chromosome organization and DNA replication, making it a key player in proper cell division and development.
Dysregulation of NIPBL has been linked to developmental disorders such as Cornelia de Lange syndrome, highlighting the importance of understanding its function. Research into the role of NIPBL can provide valuable insights into the mechanisms underlying these disorders and may lead to the development of targeted therapies in the future.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO50678 at dilution of 1:100.
Western Blot.
Background:
Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).
Synonyms:
Nipped-B-like protein (Delangin) (SCC2 homolog), NIPBL, IDN3 SCC2
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
