The NID1 Polyclonal Antibody (PACO28566) is a vital tool for researchers studying NID1, a key component of the extracellular matrix that plays a crucial role in cell adhesion, migration, and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and has been validated for use in Western blotting applications.NID1, also known as basement membrane-specific heparan sulfate proteoglycan core protein, is involved in various physiological processes, including tissue development and wound healing.
Its dysregulation has been implicated in various diseases, such as cancer and fibrosis, making it a promising target for therapeutic interventions. By using the NID1 Polyclonal Antibody, researchers can effectively study the expression and function of NID1 in different cell types and tissues, advancing our understanding of its role in health and disease.
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
Synonyms:
Nidogen-1 (NID-1) (Entactin), Nid1, Ent
UniProt Protein Function:
Nidogen-1: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptideCellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular region; basement membrane; basal laminaMolecular Function: laminin-1 binding; collagen binding; proteoglycan binding; protein binding; extracellular matrix binding; laminin binding; calcium ion bindingBiological Process: extracellular matrix organization and biogenesis; cell-matrix adhesion; glomerular basement membrane development; cell adhesion
