The NHLRC1 Polyclonal Antibody (CAB6669) is a crucial tool for researchers studying NHLRC1, a protein involved in the regulation of autophagy and lysosomal function. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to NHLRC1, this antibody enables the detection and analysis of the protein in a variety of cell types, making it an ideal choice for studies in cell biology and neurodegenerative diseases.NHLRC1, also known as EPM2A interacting protein 2, is known to play a key role in the clearance of damaged organelles and proteins through autophagy.
Dysregulation of NHLRC1 has been linked to various neurodegenerative disorders, making it a promising target for research into conditions such as Alzheimer's disease and Parkinson's disease. Understanding the function of NHLRC1 is essential for developing therapies aimed at preserving cellular homeostasis and preventing the accumulation of toxic aggregates implicated in these diseases. Overall, the NHLRC1 Polyclonal Antibody (CAB6669) provides researchers with a valuable tool for investigating the role of NHLRC1 in cellular processes and disease pathology, paving the way for potential therapeutic interventions in the future.
Product Name:
NHLRC1 Rabbit Polyclonal Antibody
SKU:
CAB6669
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human NHLRC1 (NP_940988.2).
The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as progressive myoclonic epilepsy type 2 (EPM2).
Purification Method:
Affinity purification
Gene ID:
378884
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat heart, using NHLRC1 Rabbit pAb (CAB6669) at 1:6000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
