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NHLH1/NHLH2 Antibody (PACO00903)

SKU:
PACO00903
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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NHLH1/NHLH2 Antibody (PACO00903)

The NHLH1/NHLH2 Antibody (PACO00903) is a polyclonal antibody designed for research involving NHLH1 and NHLH2, two transcription factors involved in regulating gene expression and cell differentiation. This antibody, raised in rabbits, has been validated for use in various applications, including Western blot and immunohistochemistry, with high reactivity towards human samples.NHLH1 and NHLH2 are critical regulators of neurogenesis and neuronal differentiation, playing essential roles in the development and function of the nervous system. Dysregulation of these transcription factors has been implicated in neurological disorders, making them important targets for research in neurobiology and neurodevelopmental studies.

By using the NHLH1/NHLH2 Antibody (PACO00903), researchers can investigate the expression and function of these transcription factors in different cell types and tissues, providing valuable insights into their roles in neural development and potential implications in disease pathology. This antibody is a valuable tool for studying the complex mechanisms underlying neurogenesis and neuronal differentiation, with implications for understanding and potentially treating neurological conditions.

Antibody Name:NHLH1/NHLH2 Antibody
Antibody SKU:PACO00903
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human HEN1/2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:NHLH1; BHLHA35; HEN1; Helix-loop-helix protein 1; HEN-1; Class A basic helix-loop-helix protein 35; bHLHa35; Nescient helix loop helix 1; NSCL-1; NHLH2; BHLHA34; HEN2; KIAA0490; Helix-loop-helix protein 2; HEN-2; Class A basic helix-loop-he
UniProt Protein Function:NHLH1: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: nucleus

Biological Process: central nervous system development; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]
UniProt Code:Q02575
NCBI GenInfo Identifier:399885
NCBI Gene ID:4807
NCBI Accession:Q02575.1
UniProt Related Accession:Q02575
Molecular Weight:14,618 Da
NCBI Full Name:Helix-loop-helix protein 1
NCBI Synonym Full Names:nescient helix-loop-helix 1
NCBI Official Symbol:NHLH1  
NCBI Official Synonym Symbols:HEN1; NSCL; NSCL1; bHLHa35  
NCBI Protein Information:helix-loop-helix protein 1
UniProt Protein Name:Helix-loop-helix protein 1
UniProt Synonym Protein Names:Class A basic helix-loop-helix protein 35; bHLHa35; Nescient helix loop helix 1; NSCL-1
Protein Family:Helix-loop-helix protein
UniProt Gene Name:NHLH1  
UniProt Entry Name:HEN1_HUMAN

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