The NHEJ1 Polyclonal Antibody is a valuable tool for researchers studying DNA repair mechanisms and genomic stability. This antibody, raised in rabbits, is highly specific to NHEJ1 protein and is validated for use in Western blot applications. It enables detection and analysis of NHEJ1 in various cell types, providing valuable insights into the role of this protein in DNA double-strand break repair.NHEJ1, also known as non-homologous end joining protein 1, is an essential component of the non-homologous end joining pathway, a key mechanism for repairing DNA double-strand breaks.
Dysregulation of NHEJ1 has been linked to genetic instability and increased susceptibility to cancer and other genetic diseases. By studying NHEJ1 expression and function, researchers can gain a better understanding of how DNA repair processes contribute to maintaining genomic integrity.This NHEJ1 Polyclonal Antibody is a valuable asset for research in molecular biology, genetics, and cancer biology. Its high specificity and sensitivity make it an excellent tool for investigating the role of NHEJ1 in DNA repair and its implications for human health and disease.
Product Name:
NHEJ1 Polyclonal Antibody
SKU:
CAB21661
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human NHEJ1 (NP_079058.1).
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.
Purification Method:
Affinity purification
Gene ID:
79840
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NHEJ1 antibody (CAB21661) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
