The NGF Polyclonal Antibody (PACO33748) is a valuable tool for researchers studying nerve growth factor (NGF) and its role in various biological processes. This antibody, produced in rabbits, is highly specific for detecting NGF and has been validated for use in a variety of research applications, including Western blotting and immunohistochemistry.NGF is a protein that plays a key role in the growth, survival, and maintenance of certain nerve cells. Dysregulation of NGF signaling has been implicated in a number of neuropathies and neurodegenerative diseases, making it an important target for therapeutic development.
By using the NGF Polyclonal Antibody, researchers can gain valuable insights into the expression and localization of NGF in different cell types and tissues.This antibody is an essential tool for scientists studying neurobiology, neurodegenerative diseases, and the potential therapeutic applications of targeting the NGF pathway. With its high specificity and sensitivity, the NGF Polyclonal Antibody (PACO33748) is ideal for advancing research in these important areas of study.
Antibody Name:
Ngf Antibody (PACO33748)
Antibody SKU:
PACO33748
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IP
Recommended Dilutions:
ELISA:1:2000-1:10000, IP:1:200-1:2000
Species Reactivity:
Rat
Immunogen:
Recombinant Rat Beta-nerve growth factor protein (124-241AA)
Immunoprecipitating Ngf in Rat heart tissue Lane 1: Rabbit control IgG instead of PACO33748 in Rat heart tissue.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/5000) Lane 2: PACO33748 (8µg) + Rat heart tissue (500µg) Lane 3: Rat heart tissue (20µg) .
Background:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.
Synonyms:
Beta-nerve growth factor (Beta-NGF), Ngf, Ngfb
UniProt Protein Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.
