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Anti-NGF Antibody (CAB0258)

SKU:
CAB0258
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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Anti-NGF Antibody (CAB0258)

The NGF Polyclonal Antibody (CAB0258) is a valuable tool for researchers studying nerve growth factor (NGF), a protein crucial for the growth, maintenance, and survival of certain neurons. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in various applications, including Western blotting.NGF plays a pivotal role in the nervous system, promoting the growth and differentiation of nerve cells while also modulating pain and inflammation. Dysregulation of NGF signaling has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and neuropathic pain conditions.

By targeting NGF with this antibody, researchers can investigate its role in these diseases and potentially develop new treatment strategies.This NGF Polyclonal Antibody provides a reliable tool for detecting and analyzing NGF levels in different cell types, making it an essential component for studies in neuroscience, neurology, and drug discovery. By understanding the molecular mechanisms of NGF action, researchers can uncover potential therapeutic targets for a range of neurological conditions.

Antibody Name:Anti-NGF Antibody
Antibody SKU:CAB0258
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-241 of human NGF (NP_002497.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HL-60, HepG2, SH-SY5Y, HeLa, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-241 of human NGF (NP_002497.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EPHS ESNV PAGH TIPQ AHWT KLQH SLDT ALRR ARSA PAAA IAAR VAGQ TRNI TVDP RLFK KRRL RSPR VLFS TQPP REAA DTQD LDFE VGGA APFN RTHR SKRS SSHP IFHR GEFS VCDS VSVW VGDK TTAT DIKG KEVM VLGE VNIN NSVF KQYF FETK CRDP NPVD SGCR GIDS KHWN SYCT TTHT FVKA LTMD GKQA AWRF IRID TACV CVLS RKAV RRA
Gene ID:4803
Uniprot:P01138
Cellular Location:Secreted
Calculated MW:26kDa
Observed MW:17kDa/27kDa
Synonyms:NGF, Beta-NGF, HSAN5, NGFB
Background:This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
UniProt Protein Function:NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: cytoplasmic membrane-bound vesicle; endosome; extracellular region; Golgi lumen

Molecular Function:growth factor activity; metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding; receptor signaling protein activity

Biological Process: activation of MAPKK activity; cell-cell signaling; induction of apoptosis via death domain receptors; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of neuron apoptosis; nerve growth factor processing; nerve growth factor receptor signaling pathway; neurite morphogenesis; neuron apoptosis; peripheral nervous system development; phosphoinositide-mediated signaling; phospholipase C activation; positive regulation of apoptosis; positive regulation of axon extension; positive regulation of axonogenesis; positive regulation of collateral sprouting; positive regulation of neuron maturation; positive regulation of protein ubiquitination; Ras protein signal transduction; regulation of axonogenesis; regulation of caspase activity; regulation of neuron differentiation; regulation of neurotransmitter secretion; regulation of release of sequestered calcium ion into cytosol; sensory perception of pain; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V

NCBI Summary:This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
UniProt Code:P01138
NCBI GenInfo Identifier:90110037
NCBI Gene ID:4803
NCBI Accession:P01138.3
UniProt Secondary Accession:P01138,Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8, A1A4E5,
UniProt Related Accession:P01138
Molecular Weight:26,959 Da
NCBI Full Name:Beta-nerve growth factor
NCBI Synonym Full Names:nerve growth factor
NCBI Official Symbol:NGF  
NCBI Official Synonym Symbols:NGFB; HSAN5; Beta-NGF  
NCBI Protein Information:beta-nerve growth factor
UniProt Protein Name:Beta-nerve growth factor
Protein Family:Nerve growth factor
UniProt Gene Name:NGF  
UniProt Entry Name:NGF_HUMAN
Anti-NGF Antibody (CAB0258)Western blot analysis of extracts of various cell lines, using NGF antibody (CAB0258) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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