The NFKBIZ Polyclonal Antibody (CAB10492) is a valuable tool for researchers studying the NF-κB inhibitor zeta (NFKBIZ) protein, a key regulator of immune responses and inflammatory processes. This antibody is produced in rabbits and has been specifically validated for use in Western blot applications with human samples.NFKBIZ plays a crucial role in modulating the NF-κB signaling pathway, which is involved in regulating the expression of genes that control the immune response to various stimuli. By targeting NFKBIZ, researchers can gain valuable insights into the mechanisms underlying inflammatory diseases, autoimmune disorders, and cancer.
With its high reactivity and specificity for human samples, the NFKBIZ Polyclonal Antibody is an essential tool for studies in immunology and cancer research. Its ability to detect and analyze NFKBIZ protein levels in different cell types makes it a versatile reagent for investigating the function of this important regulator in various disease contexts.
Product Name:
NFKBIZ Rabbit Polyclonal Antibody
SKU:
CAB10492
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human NFKBIZ (NP_113607.1).
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
64332
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat lung, using NFKBIZ antibody (CAB10492) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
