NFKBID Antibody (PACO13938)
- SKU:
- PACO13938
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NFKBID Antibody (PACO13938)
The NFKBID Polyclonal Antibody (PAC013938) is a valuable tool for researchers interested in studying NFKBID, a key protein involved in the regulation of immune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the NFKBID protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.NFKBID, also known as IκBNS, is a crucial molecule that modulates the activity of NF-κB, a transcription factor involved in the regulation of genes related to inflammation and immune responses.
Understanding the function of NFKBID is essential for unraveling the complexities of immune system regulation and its dysregulation in conditions such as cancer, autoimmune diseases, and inflammatory disorders. By targeting NFKBID, researchers can gain insights into potential therapeutic strategies for manipulating immune responses in various disease contexts.
| Antibody Name: | NFKBID Antibody (PACO13938) |
| Antibody SKU: | PACO13938 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human NFKBID |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, 231 cells, Primary antibody: PACO13938(NFKBID Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO13938(NFKBID Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.I κ BNS, the nuclear I κ B-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.I κ BNS has been identified as a member of the I κ B family of NF- κ B inhibitors, which undergoes induction upon TCR signaling. I κ BNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine. |
| Synonyms: | nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, delta |
| UniProt Protein Function: | NFKBID: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes. Belongs to the NF-kappa-B inhibitor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: nucleus Molecular Function:NF-kappaB binding Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of T cell differentiation in the thymus; negative regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response |
| UniProt Code: | Q8NI38 |
| NCBI GenInfo Identifier: | 74751323 |
| NCBI Gene ID: | 84807 |
| NCBI Accession: | Q8NI38.1 |
| UniProt Secondary Accession: | Q8NI38,Q8NI39, Q9BRG9, |
| UniProt Related Accession: | Q8NI38 |
| Molecular Weight: | 150 |
| NCBI Full Name: | NF-kappa-B inhibitor delta |
| NCBI Synonym Full Names: | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta |
| NCBI Official Symbol: | NFKBIDÂ Â |
| NCBI Official Synonym Symbols: | TA-NFKBH; IkappaBNSÂ Â |
| NCBI Protein Information: | NF-kappa-B inhibitor delta; ikB-delta; ikappaBdelta; I-kappa-B-delta; T-cell activation NFKB-like protein |
| UniProt Protein Name: | NF-kappa-B inhibitor delta |
| UniProt Synonym Protein Names: | I-kappa-B-delta; IkB-delta; IkappaBdelta; IkappaBNS; T-cell activation NFKB-like protein; TA-NFKBH |
| Protein Family: | NF-kappa-B inhibitor |
| UniProt Gene Name: | NFKBIDÂ Â |
| UniProt Entry Name: | IKBD_HUMAN |
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