The NFKB2 Polyclonal Antibody (CAB5567) is a versatile tool for researchers studying the NF-kappa-B family of transcription factors, known for their role in immune response and inflammation. This antibody, produced in rabbits, is highly specific to NFKB2 and has been validated for use in various applications, including Western blot and immunohistochemistry.NFKB2 is a key player in the regulation of immune and inflammatory responses, and dysregulation of its activity has been linked to various diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions.
By targeting NFKB2 with this polyclonal antibody, researchers can gain valuable insights into the molecular mechanisms underlying these diseases, potentially leading to the development of new therapeutic interventions.Overall, the NFKB2 Polyclonal Antibody (CAB5567) is a valuable tool for scientists seeking to unravel the complexities of NF-kappa-B signaling and its impact on health and disease. Its high specificity and reliability make it an essential component of any immunology or cancer research toolkit.
Product Name:
NF-κB2 Rabbit Polyclonal Antibody
SKU:
CAB5567
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 730-900 of NF-κB2 (NP_001070962.1).
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4791
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NF-κB2 Rabbit pAb (CAB5567) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
