The NFkB1 Polyclonal Antibody (CAB14754) is an essential tool for researchers studying NFkB1, a key transcription factor involved in inflammation, immune response, and cell survival. This antibody, produced in rabbits, specifically targets NFkB1 and has been validated for use in Western blot applications. NFkB1 is a crucial regulator of gene expression in response to various stimuli, including pro-inflammatory cytokines and pathogens. Dysregulation of NFkB1 signaling has been implicated in a wide range of diseases, including cancer, autoimmune disorders, and inflammatory conditions.
By using the NFkB1 Polyclonal Antibody, researchers can accurately detect and analyze NFkB1 protein levels in different cell types, providing valuable insights into the role of NFkB1 in normal physiology and disease pathogenesis. This antibody is a valuable tool for studies in immunology, cancer biology, and inflammatory disorders, ultimately contributing to the development of novel therapeutic approaches targeting NFkB1 signaling pathways.
Product Name:
NFKB1 Rabbit Polyclonal Antibody
SKU:
CAB14754
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 41-365 of human NFKB1 (NP_001158884.1).
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
4790
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Rat testis, using NFKB1 Rabbit pAb (CAB14754) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
