NFIA/NFIB/NFIC/NFIX Antibody (PACO04425)
- SKU:
- PACO04425
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NFIA/NFIB/NFIC/NFIX Antibody (PACO04425)
The NFIA/NFIB/NFIC/NFIX Antibody (PAC04425) is a polyclonal antibody designed for research involving the NFIA, NFIB, NFIC, and NFIX transcription factors, which play crucial roles in gene regulation and development. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in various research applications such as immunofluorescence, immunohistochemistry, and Western blotting.NFIA, NFIB, NFIC, and NFIX are known for their roles in regulating gene expression and cell differentiation, making them important targets for studying development, neurogenesis, and cancer.
By using this antibody, researchers can detect and analyze the expression of these transcription factors in different cell types, helping to gain insights into their functions and molecular mechanisms.The NFIA/NFIB/NFIC/NFIX Antibody (PAC04425) is a valuable tool for researchers interested in understanding the roles of NFIA, NFIB, NFIC, and NFIX in various biological processes and diseases. Its high specificity and reactivity make it a reliable choice for studies in molecular biology, developmental biology, and cancer research.
| Antibody Name: | NFIA/NFIB/NFIC/NFIX Antibody |
| Antibody SKU: | PACO04425 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the N-terminal region of human NF-1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | NFIA; KIAA1439; Nuclear factor 1 A-type; NF1-A; Nuclear factor 1/A; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/A; NF-I/A; NFI-A; TGGCA-binding protein; NFIB; Nuclear factor 1 B-type; NF1-B; Nuclear factor 1/B; CCAAT-box-b |
| UniProt Protein Function: | NFI-A: Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 1p31.3-p31.2 Cellular Component: nucleoplasm; nucleus; cell junction Molecular Function:transcription factor binding; transcription factor activity Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; viral genome replication; DNA replication; response to organic cyclic substance |
| NCBI Summary: | This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q12857 |
| NCBI GenInfo Identifier: | 14194959 |
| NCBI Gene ID: | 4774 |
| NCBI Accession: | Q12857.2 |
| UniProt Secondary Accession: | Q12857,O00712, P08651, Q14938, |
| UniProt Related Accession: | Q12857 |
| Molecular Weight: | |
| NCBI Full Name: | Nuclear factor 1 A-type |
| NCBI Synonym Full Names: | nuclear factor I A |
| NCBI Official Symbol: | NFIAÂ Â |
| NCBI Official Synonym Symbols: | CTF; NF1-A; NFI-A; NFI-L; BRMUTD; NF-I/AÂ Â |
| NCBI Protein Information: | nuclear factor 1 A-type |
| UniProt Protein Name: | Nuclear factor 1 A-type |
| UniProt Synonym Protein Names: | CCAAT-box-binding transcription factor; CTF; Nuclear factor I/A; NF-I/A; NFI-A; TGGCA-binding protein |
| UniProt Gene Name: | NFIAÂ Â |
| UniProt Entry Name: | NFIA_HUMAN |
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