The NFE2L3 Polyclonal Antibody (CAB15761) is a valuable tool for researchers studying NFE2L3, a transcription factor involved in the regulation of genes related to oxidative stress response and detoxification. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.NFE2L3, also known as Nuclear Factor, Erythroid 2 Like 3, plays a crucial role in maintaining cellular homeostasis by controlling the expression of genes involved in antioxidant defense. Dysregulation of NFE2L3 has been implicated in various diseases, including cancer, diabetes, and neurological disorders.
Therefore, studying the activity of NFE2L3 can provide important insights into the pathogenesis of these conditions and may lead to the development of novel therapeutic strategies.By utilizing the NFE2L3 Polyclonal Antibody, researchers can accurately detect and analyze NFE2L3 protein levels in different cell types, allowing for a better understanding of its functions and regulatory mechanisms. This antibody is an essential tool for investigations in molecular biology, cell signaling, and disease mechanisms related to oxidative stress and detoxification pathways.
Product Name:
NFE2L3 Rabbit Polyclonal Antibody
SKU:
CAB15761
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human NFE2L3 (NP_004280.5).
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18.
Purification Method:
Affinity purification
Gene ID:
9603
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NFE2L3 Rabbit pAb (CAB15761) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
