UniProt Protein Function: | NF-E2: a transcription factor of the bZIP family, CNC subfamily. May play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the procurement of iron. Required for activity at the locus control region (LCR) upstream of the globin gene complexes. Requires p18 NF-E2 for binding to the NF-E2 motif. Expressed in hematopoietic cells and also in colon and testis.Protein type: DNA-binding; Transcription factor; CytoskeletalChromosomal Location of Human Ortholog: 12q13Cellular Component: actin cytoskeleton; cytoplasm; nucleoplasm; nucleusMolecular Function: protein binding; protein N-terminus binding; sequence-specific DNA binding; transcription coactivator activity; WW domain bindingBiological Process: blood circulation; blood coagulation; hemostasis; multicellular organismal development; nucleosome disassembly; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q16621 |
NCBI GenInfo Identifier: | 6831585 |
NCBI Gene ID: | 4778 |
NCBI Accession: | Q16621.1 |
UniProt Secondary Accession: | Q16621,Q07720, Q6ICV9 |
UniProt Related Accession: | Q16621 |
Molecular Weight: | 41,473 Da |
NCBI Full Name: | Transcription factor NF-E2 45 kDa subunit |
NCBI Synonym Full Names: | nuclear factor, erythroid 2 |
NCBI Official Symbol: | NFE2Â Â |
NCBI Official Synonym Symbols: | p45; NF-E2Â Â |
NCBI Protein Information: | transcription factor NF-E2 45 kDa subunit |
UniProt Protein Name: | Transcription factor NF-E2 45 kDa subunit |
UniProt Synonym Protein Names: | Leucine zipper protein NF-E2; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2 |
Protein Family: | Protein |
UniProt Gene Name: | NFE2Â Â |
UniProt Entry Name: | NFE2_HUMAN |