The NFATC4 Polyclonal Antibody (CAB17511) is a crucial tool for researchers studying NFATC4, a key transcription factor involved in the regulation of immune responses and cell differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By interacting with the NFATC4 protein, this antibody enables accurate detection and analysis in a variety of cell types, facilitating in-depth investigations in the fields of immunology and cancer research.
NFATC4, also known as nuclear factor of activated T-cells, cytoplasmic 4, plays a pivotal role in the immune system by controlling gene expression in response to various stimuli. Its involvement in immune regulation and cellular processes highlights its significance as a potential therapeutic target in conditions such as cancer, autoimmune diseases, and inflammation. By studying NFATC4 activity, researchers can gain valuable insights into disease mechanisms and develop novel treatment strategies aimed at modulating immune responses effectively.
Product Name:
NFATC4 Rabbit Polyclonal Antibody
SKU:
CAB17511
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 560-710 of human NFATC4 (NP_004545.2).
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4776
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NFATC4 Rabbit pAb (CAB17511) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
