The NFATC2 Polyclonal Antibody (CAB3107) is a valuable tool for researchers studying NFATC2, a key transcription factor involved in immune response and T cell activation. This antibody is sourced from rabbits and demonstrates high reactivity with human samples, making it suitable for use in techniques such as Western blotting.NFATC2, also known as Nuclear Factor of Activated T-cells 2, plays a crucial role in the regulation of genes involved in the immune system, making it a significant target for research in immunology and cancer biology. By binding specifically to NFATC2 protein, this antibody enables precise detection and analysis in various cell types, providing insights into the function and regulation of this transcription factor.
Understanding the mechanisms by which NFATC2 influences immune response and T cell activation is essential for developing targeted therapies in areas such as cancer immunotherapy and autoimmune diseases. By utilizing the NFATC2 Polyclonal Antibody, researchers can further explore the role of NFATC2 in these contexts and uncover potential therapeutic interventions.
Product Name:
NFATC2 Rabbit Polyclonal Antibody
SKU:
CAB3107
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NFATC2 (NP_775114.1).
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Purification Method:
Affinity purification
Gene ID:
4773
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using (CAB3107) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
