The NFAT2 Rabbit Monoclonal Antibody (CAB19597) is a powerful tool for researchers investigating NFAT2, a transcription factor involved in immune cell activation and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it an excellent choice for Western blot and immunohistochemistry applications.NFAT2, also known as Nuclear Factor of Activated T cells 2, plays a crucial role in regulating gene expression in immune cells, particularly T cells. It is a key player in immune responses, influencing processes such as cytokine production and cell proliferation.
Dysregulation of NFAT2 has been implicated in various immune-related diseases, including autoimmune disorders and allergies.By using the NFAT2 Rabbit Monoclonal Antibody, researchers can confidently study the expression and activity of NFAT2 in different cell types and experimental conditions. This antibody opens up opportunities for in-depth investigations into the role of NFAT2 in immunology and potential therapeutic strategies targeting this transcription factor.
Product Name:
NFAT2 Rabbit Monoclonal Antibody
SKU:
CAB19597
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 844-943 of human NFAT2 (O95644).
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
Purification Method:
Affinity purification
Gene ID:
4772
Clone Number:
ARC0076
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NFAT2 antibody (CAB19597) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
