The NF2 Polyclonal Antibody (CAB13626) is a valuable tool for research involving NF2, a tumor suppressor protein associated with neurofibromatosis type 2. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting NF2 in human samples, making it ideal for applications such as Western blotting.NF2 plays a critical role in regulating cell growth and division, particularly in the nervous system. Mutations in the NF2 gene are linked to the development of various tumors, including schwannomas and meningiomas.
By targeting NF2 with this antibody, researchers can investigate its function and potential therapeutic implications in cancer biology and neurofibromatosis research.The NF2 Polyclonal Antibody is a reliable tool for studying the molecular mechanisms underlying NF2-related diseases. Its specificity and versatility make it a valuable asset for researchers exploring the role of NF2 in tumorigenesis and potential therapeutic interventions.
Product Name:
[KO Validated] NF2 Rabbit Polyclonal Antibody
SKU:
CAB13626
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 477-576 of human NF2 (NP_000259.1).
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities.
Purification Method:
Affinity purification
Gene ID:
4771
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using [KD Validated] NF2 Rabbit pAb (CAB13626) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
